The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor−/Progesterone Receptor−/HER-2− Breast Carcinomas
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چکیده
منابع مشابه
The Relationship Between Fibroblastic Growth Factor Receptor-1 (FGFR1) Gene Amplification in Triple Negative Breast Carcinomas and Clinicopathological Prognostic Factors
Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, differentiation, and migration of malignant cells. The objective was t...
متن کاملCharacterization of immunohistochemical markers in triple negative breast carcinomas.
PURPOSE Triple negative (TN) breast carcinomas (estrogen receptor/ER, progesterone receptor/PR and HER-2/neu negative) constitute 15-25% of all breast carcinomas and have been correlated with aggressive behavior and poor prognosis. Our aim was to describe and characterize the immunophenotype of these tumors in a group of patients from Turkey. METHODS We used the immunohistochemical markers CK...
متن کاملGene Expression Changes in Pomegranate Peel Extract-Treated Triple-Negative Breast Cancer Cells
Background: Triple-negative breast cancer (TNBC) is treated with highly aggressive non-targeted chemotherapies. Safer and more effective therapeutic approaches than those currently in use are needed. Natural pomegranate peel extract (PPE) has recently been found to inhibit breast cancer progression; however, its mechanisms of action remain unclear. We hypothesized that transcriptional chan...
متن کاملDynamic contrast-enhanced MRI in Triple Negative Breast Carcinomas: is there a distinct imaging phenotype?
S. P. Li, N. J. Taylor, J. J. Stirling, M-L. W. Ah-See, M. J. Beresford, D. J. Collins, J. A. d'Arcy, A. Makris, and A. R. Padhani Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom, Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom, CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutto...
متن کاملExpression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients
African American women suffer higher incidence and mortality of triple negative breast cancer (TNBC) than Caucasian women. TNBC is very aggressive, causing the worst clinical outcome. We previously demonstrated that tumors from these patients express high IGF-II and exhibit high activation of the IGF signaling pathways. IGF-II gene expression is imprinted (monoallelic), promotes tumor progressi...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2007
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-3545